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Augmentin is a penicillin-like antibiotic that contains a combination of amoxicillin and clavulanic acid or clavulanate potassium. It belongs to a class of drugs known as beta lactamase inhibitors. The drug is used to treat a wide variety of bacterial infections.

It is important to note that Augmentin will not work for viral infections like common cold or flu. The medicine can come as tablets (regular tablets, extended release, and chewables tablets) as well as liquid suspensions. You should use this drug for only the bacteria that is susceptible to it.

Uses of Augmentin

Doctor's prescribe Augmentin for a number of bacteria infections like:

  • Urinary tract infections
  • Pneumonia
  • Sinusitis
  • Bronchitis and bronchiolitis
  • Ear infections
  • Infections of the skin

Your doctor may also prescribe augmentin for other infections not listed above.

How Does Augmentin Work?

Augmentin is a wonder drug. The Amoxicillin component interrupts bacteria cell wall formation by binding to penicillin-binding proteins on the bacteria cell wall. This bond breaks the structural integrity of the bacterial cell wall, making the bacteria prone to death by lysis.

The clavulanate potassium, on the other hand, is a beta lactamase inhibitor. Beta lactamase are enzymes produced by bacteria to counter the effects of penicillin-like antibiotics like amoxicillin. Clavulanate potassium inhibits these enzymes and allows the amoxicillin to continue killing the bacteria cells

Precautions

Before consuming Augmentin, you should adhere to these instructions:

  • Do not use this drug if you are allergic to amoxicillin or clavulanate.
  • Avoid using this medicine if you have any of the following:

○     A severe kidney disease or you are on dialysis

○     Liver disease or jaundice while taking Augmentin in the past

○     Allergies to other penicillin or cephalosporin antibiotics

  • To be sure this drug is safe for you, tell your doctor if you have mononucleosis or phenylketonuria as the liquid forms may contain phenylalanine.
  • Augmentin makes birth control pills ineffective, inform your doctor if you are on one.
  • Inform your doctor if you are pregnant or breastfeeding before taking this drug.
  • Augmentin should not be given to a child without medical advice.

How to Use Augmentin

Take this drug exactly as directed by your doctor, and ensure you complete your treatment. Do not stop taking it even if you feel better as this may lead to incomplete infection treatment and possible bacterial resistance.

Augmentin is to be taken by mouth, with or without food. However, clavulanate potassium needs food for optimal absorption and reduction in possible gastrointestinal discomfort. The medicine should be taken every 8 or 12 hours daily (2 to 3 times daily).

While other tablets should be taken with a glass of water, the chewable ones should be thoroughly chewed before swallowing. Additionally, the liquid suspension should be mixed thoroughly and measured with a measuring device.

Side Effects of Augmentin

The common side effects of this drug are mild and include:

  • Nausea
  • Diaper rash
  • Vomiting
  • Vaginal itching with or without discharge
  • Rash
  • Diarrhea
  • Stomach discomfort

Call your doctor immediately if you experience any of the following:

  • Darkening of urine
  • Yellowing of eyes and skin
  • Unusual tiredness
  • Easy bruising
  • Uncontrolled vomiting
  • Blood/or mucus in stool
  • Trouble swallowing or breathing
  • Swellings on the lips, face, or eyes
  • Unexplained fever that doesn't go away
  • Lymph node swelling

You can consult your doctor for all the possible side effects of this drug.

Augmentin Dosing Information

The dosage to take is dependent on your weight and age as well as the severity of the infection as determined by a doctor. Pediatric patients who weigh 40 kg and above are given adult doses. Though not all with kidney impairment needs dosage modification, your doctor will modify your dose after accessing the level of kidney impairment you may have.

The higher the dose, the wider the time interval. Doses between 500-875 mg are taken every 12 hours, while doses between 250-500 mg are taken 8 hourly depending on the severity of the infection.

Because Augmentin is a prescription-only drug, your doctor will prescribe the quantity and duration of Augmentin suitable for you.

Interactions

Augmentin interacts with the following disease conditions:

  • Renal dysfunction
  • Colitis
  • Hemodialysis
  • Phenylketonuria (PKU)
  • Mononucleosis
  • Hepatotoxicity
  • Diabetes

Though Augmentin interacts with 70 drugs, only 14 of them listed below are known to be major drug interactions:

  • Amoxicillin
  • Ketoconazole
  • Bacillus calmette guerin (BCG)
  • Methotrexate
  • Cholera vaccine live
  • Mycophenolic acid
  • Lomitapide
  • Typhoid vaccine live
  • Mipomersen
  • Pexidartinib
  • Leflunomide
  • Fecal microbiota spores live
  • Mycophenolate mofetil
  • Levoketoconazole

Missed Dose and Overdose

If you miss a dose, take it as soon as you can remember. But if the time you remembered it is closer to your next dose, skip the missed dose. Inform your doctor about incidences of missed doses. If you suspect overdose or accidental poisoning, call 911 or the poison control center in your area.

Storage

Tablets should be stored at room temperature away from moisture, direct sunlight, and heat. The suspensions should be refrigerated and discarded 7 days after opening the bottle.

 

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