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Accutane is a medication for treating severe forms of acne, and it comes in the form of a capsule. This drug is a form of vitamin A, and it reduces the amount of oil produced by the oil glands. This way, the skin can renew itself faster.


Accutane is a medication that is related to vitamin A and is used to treat severe acne. It makes the oil glands in the skin release less oil and helps the skin renew itself faster.

Accutane was first discovered by Werner Bollag at Roche Laboratories in the 1960s. The original purpose of this medication was to treat skin cancer, but further experiments showed that this drug was ineffective. However, it was discovered that Accutane could be useful for the treatment of acne.

Before this idea could progress further, it was also discovered that this medication could lead to birth defects. Hence, Roche Laboratories abandoned the product.

In 1979, however, Accutane returned when a medical article showed the effectiveness of this drug in treating conglobate and cystic acne. By 1982, the Food and Drug Administration had approved the application of this drug for treating acne.


Accutane is prescribed by doctors to treat the following:

  • Severe cystic acne (nodular acne)
  • Severe rosacea
  • Hidradenitis suppurativa
  • Xeroderma pigmentosum
  • Harlequin ichthyosis
  • Lamellar ichthyosis
  • Neuroblastoma
  • Fibrodysplasia ossificans progressiva
  • Genital warts

Consumption and Dosage

Following your doctor’s instructions is the best way to take Accutane. You can also follow the directions on the label of the medication.

Take Accutane with a full glass of water, and never suck or chew on the capsule. Some medical experts might advise you to take this medication with food, while others might advise against that. Always follow the instructions of your doctor, as there is a reason for their advice.

However, food helps to increase the absorption of this medication into your bloodstream.


Adult dose:

  • Maintenance dose: 0.25 to 0.5 mg/kg/day, two times a day
  • Maximum dose: up to 2 mg/kg/day
  • Duration of therapy: up to 20 weeks

Pediatric dose:

  • Maintenance dose: 0.25 to 0.5 mg/kg/day, two times a day
  • Maximum dose: 2 mg/kg/day
  • Duration of therapy: up to 20 weeks


It can take up to two months before you notice the full benefit of Accutane. Your acne may also become worse during the first few days of taking this drug.

If severe acne returns after you have stopped taking this drug for two months, you can start on a second course of treatment. Long-term use of Accutane is not recommended, so never take more than the recommended dose.

What Happens If I Stop or Miss Doses?

Consult your doctor if you stopped taking your doses, so they can advise you on when to begin once more. If you missed a dose of Accutane, just move on to the next one. Don’t try to take two doses at once.

Side Effects

Some of the risks to come to terms with when taking Accutane include:

  • Dry lips
  • Nosebleeds
  • Thinning hair
  • Minor swelling of the eyelids
  • Upset stomach
  • Crusty skin

You can relieve dry lips by sucking on sugarless hard candy, chewing on sugarless gum, or drinking water. The above side effects should only alarm you when they last or get worse. At that point, you need to contact your pharmacist or doctor.

There are more serious side effects that could come from taking Accutane, and they include:

  • Depression
  • Suicidal thoughts
  • Anxiety
  • Peeling skin on the palms and soles
  • Sore throat
  • Fever
  • Painful swallowing
  • Tingling feeling in the skin
  • Muscle pain
  • Pancreatitis

Tell your doctor immediately if you develop any of the above side effects. There are worse side effects that will require you to stop taking this drug and immediately contact your doctor, and these include:

  • Headache
  • Chest pain
  • Vomiting that doesn’t stop
  • Hearing loss
  • Severe stomach pain
  • Severe diarrhea
  • Ringing in the ears
  • Yellowing eyes
  • Rectal bleeding
  • Vision changes
  • Dark urine
  • Trouble breathing


Accutane is a vitamin A drug, so inform your doctor if you’re allergic to vitamin A-related drugs. It’s also good to inform your doctor if you have any other allergies as well. This way, they can advise you if the drug has any inactive ingredients that can trigger your allergies.

Pregnant women are advised to avoid this medication, as it can cause birth defects, premature births, or miscarriages. Women are also advised to abstain from sex or take birth control medication one month before using Accutane. They should also follow this pattern for one month after stopping this medication.

Inform your doctor about your medical history before taking Accutane, especially if you have a family or personal history of:

  • High blood fat
  • Osteoporosis
  • Liver disease
  • Obesity
  • Alcohol abuse
  • Eating disorders
  • Pancreatitis

Do not donate blood while taking Accutane or for one month after you stop taking it. Limit your time in the sun, as this medication can make you sensitive to sunlight.

Bottom Line

Accutane is a drug for treating acne that hasn’t responded to antibiotics or other treatments. There is a need for strict adherence to dosages when taking this drug. Women who take his medication should take steps to ensure they don’t get pregnant while using it. If a woman has sexual intercourse while taking Accutane, she should stop this medication immediately and contact her doctor.


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